Pharmacokinetic studies of the recombinant chicken interferon-α in broiler chickens

Pharmacokinetic studies of the recombinant chicken interferon-α in broiler chickens

In this study, 24 male and female broiler chickens at 30-day-old were divided into three groups with 8 animals in each group. The animals were administered with recombinant chicken interferon-α (rChIFN-α) at a dose of 1.0 × 106 IU/kg intravenously, intramuscularly or subcutaneously, respectively. Serum samples were collected at different time points post administration, and the titers of rChIFN...

Ochratoxicosis in Broiler Chickens:

This experiment was conducted to evaluate the effects of ochratoxin A (OTA) on the function and histology of the liver, kidney and bursa of broiler chickens fed OTA contaminated rations. Two hundred forty one-day-old male Ross broiler chicks were used, they were randomly divided into 3 dietary experimental groups of 80 birds and given rations containing 0 (control), 400 or 800 μg OTA/Kg feed. T...

Pathomicrobial studies on Salmonella Gallinarum infection in broiler chickens

Aim: To conduct detailed pathomicrobial studies on Salmonella Gallinarum infection in broiler chickens. Materials and Methods: Bacteriological and pathological studies were conducted on 134 dead poultry birds collected from 23 different farms suspected to be infected with S. Gallinarum. Results: Mortality pattern revealed that maximum mortality occurred in 1-2 week aged birds. Out of 23 Salmone...

The Welfare of Broiler Chickens

The Effect of Heat Shock on Production of Recombinant Human Interferon Alpha 2a (rhIFN α -2a) by Escherichia coli

Recombinant human interferon alpha 2a (rhIFN α -2a) production and cell growth were monitored in a set of genetically modified E. coli strains (MSD1519, MSD1520, MSD 1521, MSD 1522, MSD 1523) producing rhIFN α -2a. The growth was followed at OD 600 nm, changes in cell physiology were detected by pyrolysis mass spectrometry (PyMS) of cell biomass and recombinant protein production was determined...